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A separate national cohort study published in the Lancet Psychiatry, using Swedish health registers and a within-individual design comparing use versus non-use in the same 95,490 people with existing depression or anxiety, reached almost the opposite conclusion: semaglutide was associated with a 42% lower risk of mental illness worsening overall (aHR 0.58, 95% CI 0.51-0.65), including a 44% lower risk of worsening anxiety (aHR 0.62) and a 44% lower risk of worsening depression (aHR 0.56) [2]
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